NH2-PEG6-Boc |
| カタログ番号GC64153 |
NH2-PEG6-Boc は、PROTAC の合成に使用できる PEG ベースの PROTAC リンカーです。 NH2-PEG6-Boc は、抗体薬物コンジュゲート (ADC) の合成に使用される非切断型 6 ユニット PEG ADC リンカーでもあります。
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Cas No.: 1286281-32-0
Sample solution is provided at 25 µL, 10mM.
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NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
[1]. Foley CA, et al. Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay. ACS Chem Biol. 2020 Jan 17;15(1):290-295.
[2]. Kenneth John DIRICO, et al. Spliceostatin analogs. WO2014068443A1.
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