Nogalamycin (Synonyms: NSC 70845, U 15167) |
| カタログ番号GC44438 |
CCG-273220 は、G タンパク質共役受容体 (GPCR) キナーゼ 5 (GRK5) の共有結合阻害剤であり、IC50 値は 220 nM です。 CCG-273220 は、GRK5 サブファミリー特異的残基である Cys474 を共有ハンドルとして結合することにより、GRK2 よりも GRK5 に対して高度に選択的です (IC50 = 350 μM)。
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Cas No.: 1404-15-5
Sample solution is provided at 25 µL, 10mM.
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Nogalamycin is an anthracycline originally isolated from S. nogalater and a DNA-intercalating agent. It inhibits the DNA-unwinding and ATPase activities of P. falciparum DNA helicase 60 (IC50s = 2 and 0.5 μM, respectively) and the DNA cleavage activity of vaccinia virus topoisomerase (IC50 = 0.7 μM). Nogalamycin also inhibits the growth of MCF-7 and MDA-MB-231 human breast cancer cells (IC50s = 0.242 and 0.37 μM, respectively).
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