RU 24969 hemisuccinate |
| カタログ番号GC50006 |
RU 24969 ヘミコハク酸は優先的な 5-HT1B アゴニストであり、Ki は 0.38 nM ですが、5-HT1A 受容体に対してもかなりの親和性を示し (Ki = 2.5 nM)、脳内の他の受容体部位に対しては親和性が低くなります。
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Cas No.: 66611-27-6
Sample solution is provided at 25 µL, 10mM.
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Potent 5-HT1A/1B and moderate 5-HT2C agonist that may also release 5-HT. Centrally active following systemic administration.
Gudermann et al (1993) Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine1E-like serotonin receptor. Mol.Pharmacol. 43 412 PMID:8450834 |Tomkins and O'Neill (2000) Effect of 5-HT1B receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacol.Biochem.Behav. 66 129 PMID:10837852 |Guillaume et al (1987) Synthesis of 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles and study of their serotonergic and antiDArgic properties. Eur.J.Med.Chem. 22 33
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