Orexin B amide (mouse, rat) (trifluoroacetate salt) (Synonyms: Hypocretin 2, OXB, RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2)

Orexin B is a hypothalamic neuropeptide that regulates feeding behavior, wakefulness, and behavior under situations of high motivational relevance.¹ The sequence of mouse orexin B is identical to the rat sequence and differs from the human sequence at only two residues.² Orexin B is an agonist of orexin receptors (OXRs) that increases intracellular calcium mobilization in HEK293 cells expressing OX₁R or OX₂R (EC₅₀s = 0.93 and 0.13 µM, respectively).³

1.Mahler, S.V., Moorman, D.E., Smith, R.J., et al.Motivational activation: A unifying hypothesis of orexin/hypocretin functionNat. Neurosci.17(10)1298-1303(2014) 2.Sakurai, T., Amemiya, A., Ishii, M., et al.Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviorCell92(4)573-585(1998) 3.Lang, M., SÖll, R.M., DÜrrenberger, F., et al.Structure-activity studies of orexin A and orexin B at the human orexin 1 and orexin 2 receptors led to orexin 2 receptor selective and orexin 1 receptor preferring ligandsJ. Med. Chem.47(5)1153-1160(2004)