Oxantel pamoate (Oxantel embonate) |
| カタログ番号GC32176 |
Oxantel pamoate (Oxantel embonate) は広く入手可能な駆虫剤であり、鞭虫および鉤虫に対して強力です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 68813-55-8
Sample solution is provided at 25 µL, 10mM.
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Oxantel pamoate is a widely available dewormer, potently against Trichuris muris and Hookworms.
The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostoma ceylanicum and Necator americanus. An ED50s of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI)=2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin using ratios based on their ED50s reveals antagonistic effects (CI=1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus[1].
[1]. Keiser J, et al. Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug. PLoS Negl Trop Dis. 2013;7(3):e2119.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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