Palmarumycin C3

Palmarumycin C3 is a spirobisnaphthalene fungal metabolite that has been found in C. palmarum and has diverse biological activities.^1,2 It is active against the bacteria A. tumefaciens, B. subtilis, P. lachrymans, R. solanacearum, S. haemolyticus, and X. vesicatoria (MICs = 6.25, 6.25, 12.5, 12.5, 6.25, and 6.25 µg/ml, respectively).² Palmarumycin C3 is also active against the fungi M. microspora and E. repens, as well as the plant pathogenic fungi F. oxysporum and U. violacea, in agar diffusion assays when used at a concentration of 0.5 mg/disc.¹ It scavenges DPPH radicals in cell-free assays and has antioxidant activity in a β-carotene-linoleic acid bleaching assay (IC₅₀s = 37.57 and 7.41 µg/ml, respectively).

1.Krohn, K., Michel, A., FlÖrke, U., et al.Biologically active metabolites from fungi, 5. Palmarumycins C1-C16 from Coniothyrium sp.: Isolation, structure elucidation, and biological activityEur. J. Org. Chem.1994(11)1099-1108(1994) 2.Mou, Y., Meng, J., Fu, X., et al.Antimicrobial and antioxidant activities and effect of 1-hexadecene addition on palmarumycin C2 and C3 yields in liquid culture of endophytic fungus Berkleasmium sp. Dzf12Molecules18(12)15587-15599(2013)