Pantoprazole (Synonyms: BY 1023, SKF 96022) |
| カタログ番号GC12718 |
パントプラゾール (BY10232) は、経口で有効な強力なプロトンポンプ阻害剤 (PPI) です 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 102625-70-7
Sample solution is provided at 25 µL, 10mM.
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Pantoprazole is an inhibitor of H+/K+-ATPase [1].
Pantoprazole inhibits the activity of H+/K+-ATPase proton pumb in the parietal cells of gastric mucosa. This inhibition affects the acid secretion and thus, pantoprazole are used as drugs for the treatment of various acid-related disorders. Pantoprazole is activated slowly. The activated sulfonamide of pantoprazole binds to Cys813 and Cys822 of the pumb and inhibits acid secretion selectively. Pantoprazole inhibited lysosomal acidification with IC50 value of 194 μM. The pKa values of pantoprazole are 3.83 (pKa1) and 0.11 (pKa2). Besides that, pantoprazole also shows antibacterial effects on Helicobacter pylori [1, 2].
References:
[1] Jungnickel P W. Pantoprazole: a new proton pump inhibitor. Clinical therapeutics, 2000, 22(11): 1268-1293.
[2] Sachs G, Shin J M, Howden C W. Review article: the clinical pharmacology of proton pump inhibitors. Alimentary pharmacology & therapeutics, 2006, 23(s2): 2-8.
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