PGS-IN-1 (KME-4) (Synonyms: KME-4) |
| カタログ番号GC32038 |
PGS-IN-1 (KME-4) は、IC50 が 0.28 μM のプロスタグランジン合成酵素 (PGS) の強力な阻害剤です。また、1.05 μM の IC50 で 5-リポキシゲナーゼを阻害します。
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Cas No.: 102271-49-8
Sample solution is provided at 25 µL, 10mM.
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PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM.
The synthesized α-benzulidene-γ-butyrolactones are pure isomers (either cis or trans). PGS-IN-1 is the trans isomer. PGS-IN-1 exhibits potent antiinflammatrory and PGS inhibitory activity (IC50=0.28 μM). PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase (IC50=1.05 μM)[1].
[1]. Katsumi I, et al. Studies on styrene derivatives. I. Synthesis and antiinflammatory activities of alpha-benzylidene-gamma-butyrolactone derivatives. Chem Pharm Bull (Tokyo). 1986 Jan;34(1):121-9.
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