Pilsicainide (hydrochloride) (Synonyms: SUN 1165) |
| カタログ番号GC49193 |
ピルシカイニド (塩酸塩) (SUN-1165) は、経口で活性なナトリウムチャネル遮断薬であり、強力なクラス Ic 抗不整脈薬です。
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Cas No.: 88069-49-2
Sample solution is provided at 25 µL, 10mM.
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Pilsicainide is a class Ic antiarrhythmic agent.1,2 It shortens action potential duration in canine Purkinje fibers, as well as increases the ratio of the effective refractory period to the duration of action potential in guinea pig atrial muscle strips, when used at a concentration of 10 µg/ml.1 Pilsicainide (3-10 mg/kg) restores sinus rhythm in a canine model of ventricular multifocal arrhythmias.2 It also suppresses arrhythmias induced by ouabain or halothane and epinephrine in dogs. Formulations containing pilsicainide have been used in the treatment of supraventricular and ventricular tachycardia.
1.Hattori, Y., Inomata, N., Aisaka, K., et al.Electrophysiological actions of N-(2,6-dimethylphenyl)-8-pyrrolizidine-acetamide hydrochloride hemihydrate (SUN 1165), a new antiarrhythmic agentJ. Cardiovasc. Pharmacol.8(5)998-1002(1986) 2.Aisaka, K., Hidaka, T., Inomata, N., et al.N-(2,6-Dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate (SUN 1165): A new potent and long-acting antiarrhythmic agentArzneimittelforschung35(8)1239-1245(1985)
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