Pom-8PEG |
| カタログ番号GC63149 |
Pom-8PEG、E3 リガーゼ リガンド-リンカー複合体は、E3 ユビキチン リガーゼのセレブロン (CRBN) リガンドと 8 ユニット PEG リンカーを組み込んでいます。 Pom-8PEG は、IDO1 PROTAC デグレーダーなどの PROTAC の合成に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2488761-03-9
Sample solution is provided at 25 µL, 10mM.
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Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader[1].
[1]. Hu M, et al. Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1. Acta Pharm Sin B. 2020;10(10):1943-1953.
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