Pramlintide (acetate hydrate) |
| カタログ番号GC44674 |
プラムリンチドは、25番、28番、29番の位置に置換されたプロリン残基を含む抗糖尿病ペプチドホルモンアミリンの非アミロイド原性アナログです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 196078-30-5
Sample solution is provided at 25 µL, 10mM.
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Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively). Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner. In vivo, pramlintide (200 pg/kg) reduces brain levels of amyloid-β (1-40) and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer's disease.
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