Prostaglandin A1 (Synonyms: PGA1) |
| カタログ番号GC18310 |
プロスタグランジンA1（PGA1）は、人間の精液に含まれるPGE1化合物の脱水生成物として最初に単離されました。
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Cas No.: 14152-28-4
Sample solution is provided at 25 µL, 10mM.
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Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen.[1] It has been shown to cause renal vasodilation, increased urine sodium excretion, and lowered arterial pressure in hypertensive patients.[2] It also has growth-inhibitory activity on tumor cells; the IC50 value for the inhibition of human ovarian cancer is 7.5 µM.[3]
Reference:
[1]. Hamberg, M., and Samuelsson, B. Prostaglandins in human seminal plasma. The Journal of Biological Chemisty 241, 257-263 (1966).
[2]. Krakoff, L.R., Vlachakis, N., Mendlowitz, M., et al. Differential effect of prostaglandin A1 in hypertensive patients with low, normal and high renin. Clinical Science and Molecular Medicine 48, 311s-313s (1975).
[3]. Kikuchi, Y., Kita, T., Hirata, J., et al. Preclinical studies of antitumor prostaglandins by using human ovarian cancer cells. Cancer Metastasis Rev. 13(3-4), 309-315 (1994).
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