(Rac)-Lanicemine |
| カタログ番号GC61446 |
(Rac)-ラニセミン ((Rac)-AZD6765) は、ラニセミンのラセミ体です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 61890-25-3
Sample solution is provided at 25 µL, 10mM.
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(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].
Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1].Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1]. Animal Model: Male Sprague-Dawley rats[1]
[1]. Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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