Vofopitant dihydrochloride (Synonyms: GR 205171A) |
| カタログ番号GC37918 |
ボフォピタント二塩酸塩 (GR 205171A) は、強力で選択的な経口投与可能なタキキニン ニューロキニン 1(NK1) 受容体アンタゴニストであり、ラットおよびヒトの膜でそれぞれ 9.5 および 10.6 の pKi 値で NK1 受容体への [3H]SP 結合を阻害し、潜在的な広域制吐剤。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 168266-51-1
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent[1]. pKi: 9.5 (NK1, rat), 10.6 (NK1, human)[1]
[1]. Gardner CJ, et al. GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity. Regul Pept. 1996 Aug 27;65(1):45-53.
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *