Membrane Transporter/Ion Channel

3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals [1] [2] . 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits [2] .

8-BuS-AMP is a NTPDase1 inhibitor and a CD73/CD39 inhibitor, with an IC 50 of 35 μM and a K i value of 0.292 μM against human NTPDase1; its K i values against human CD73 and CD39 are 1.19 μM and 0.847 μM, respectively.

ABCA1 inducer 2 is a non-lipotropic ABCA1 inducer.

ADWX 1 TFA is a new peptide inhibitor that is potent and selective for Kv1.3 with an IC 50 value of 1.89 pM.

is an SNCA -targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control [1] .

Amlodipine-d 4 (maleate) is the deuterium labeled Amlodipine maleate.

ANO1-IN-4 (Compound 10bm) is a reversible inhibitor for calcium-activated chloride channel transmembrane protein 16A ( TMEM16A, also known as ANO1 ) with an IC 50 of 0.030 µM.

ARGX-119 is a first-in-class humanized agonist monoclonal antibody specific for muscle-specific kinase ( MuSK ).

BGT1-IN-1 (compound 9) is a potent BGT1 inhibitor with IC 50 value of 13.9, 58.3 µM for hBGT1, GAT3, respectively.

Blixeprodil (GM-1020) is an orally active, blood-brain barrier-penetrant NMDA receptor inhibitor with a K i of 3.25 µM in rat cortical tissues.

Zefamenib (BN-104) is an effective selective brain membrane protein inhibitor with oral activity, and it's also a Menin inhibitor, it can block the Menin-MLL interaction and leads to the degradation of Menin protein.

Caramboxin is a phenylalanine-like α -amino acid neurotoxin found in star fruit ( Averrhoa carambola ) with glutamatergic ionotropic action.

Carbamazepine-d 8 is the deuterium labeled Carbamazepine.

Cefepime-d 3 (BMY-28142-d 3 ) sulfate is deuterium labeled Cefepime sulfate.

Chlorotoxin TFA is a peptide isolated from the venom of the scorpion Leiurus quinquestriatus, acts as a chloride channel blocker [1] . Anti-cancer activity [2] .

cis-KV1.3-IN-1 (Compound cis-18) is a cis-isomer of KV1.3-IN-1.

CLH304a (compound 14) is a specific and noncompetitive GABA B receptor negative allosteric modulator (NAM).

CM-TPMF is a K( Ca )2 channel modulator with selective activation and inhibition of K( Ca )2.1 subtypes.

CMP233 is a potent antagonist of TRPM4, with the IC 50 of 0.15 μM.

Corza6 is a potent and selective human voltage-gated proton channel (hHv1) peptide inhibitor.

CPI1 is a multidrug resistance protein 1 ( MRP1 ) inhibitor with a K i value of 100 nM.

Creatinine-d 5 is the deuterium labeled Creatinine.

Crisugabalin is an orally active, selective ligand for the α2δ subunit of voltage-gated calcium channels, with a target IC 50 of 3.96 nM in rats.

Cryosim-3 is a selective TRPM8 receptor agonist.