Ribostamycin Sulfate |
| カタログ番号GC16370 |
硫酸リボスタマイシン (硫酸ビスタマイシン) は広域抗菌薬であり、30S および 50S リボソーム サブユニット結合のレベルで細菌のタンパク質合成を阻害し、薬物動態および腎毒性研究で使用されるタンパク質ジスルフィド イソメラーゼ (PDI) のシャペロン活性も阻害します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 53797-35-6
Sample solution is provided at 25 µL, 10mM.
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Ribostamycin is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies
References:
[1]. Baud H, et al. Ribostamycin, as an intermediate in the biosynthesis of neomycin. J Antibiot (Tokyo). 1977 Sep;30(9):720-3.
[2]. Hunfeld KP, et al. In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid against Borrelia burgdorferi. Int J Antimicrob Agents. 2001 Mar;17(3):203-8.
[3]. Horibe T, et al. Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Biochem Biophys Res Commun. 2001 Dec 21;289(5):967-72.
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