RR-11a analog |
| カタログ番号GC65451 |
RR-11a 類似体は、マンソン住血吸虫レグマインの強力かつ不可逆的な阻害剤であり、IC50 は 31 nM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 685543-66-2
Sample solution is provided at 25 µL, 10mM.
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RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC50 of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor[1][2].
RR-11a analog has a half-live of 3-10 min[2].
[1]. GÖtz MG, et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51(9):2816-32.
[2]. Ekici OD, et al. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 8;47(8):1889-92.
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