RR-11a analog |
| Katalog-Nr.GC65451 |
Das RR-11a-Analogon ist ein potenter und irreversibler Inhibitor von Schistosoma mansoni legumain mit einem IC50 von 31 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 685543-66-2
Sample solution is provided at 25 µL, 10mM.
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RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC50 of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor[1][2].
RR-11a analog has a half-live of 3-10 min[2].
[1]. GÖtz MG, et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51(9):2816-32.
[2]. Ekici OD, et al. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 8;47(8):1889-92.
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