RR-11a |
| カタログ番号GC33063 |
RR-11a は、レグマインの合成酵素阻害剤です (IC50=31-55 nM)。 RR-11a は、がんおよび急性心筋梗塞 (AMI) の研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1361390-56-8
Sample solution is provided at 25 µL, 10mM.
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RR-11a is a synthetic enzyme inhibitor of Legumain.
Legumain-targeted RR-11a-coupled nanoparticles reveal high ligand-receptor affinity, enhance solid-tumor penetration and uptake by tumor cells[1].
Treatment of tumor-bearing mice with RR-11a-coupled NPs encapsulating doxorubicin results in improved tumor selectivity and drug sensitivity, leading to complete inhibition of tumor growth[1].
[1]. Liao D, et al. Synthetic enzyme inhibitor: a novel targeting ligand for nanotherapeutic drug delivery inhibiting tumor growth without systemic toxicity. Nanomedicine. 2011 Dec;7(6):665-73.
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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