(S)-IDO1-IN-5 |
| カタログ番号GC38878 |
（Ｓ）－ＩＤＯ１－ＩＮ－５（実施例１Ｂ）は、ＩＤＯ１－ＩＮ－５の活性Ｓ異性体である。 (S)-IDO1-IN-5 は、1.5 μM 未満の IC50 値で IDOL に結合します。 IDO1-IN-5 は、インドールアミン 2,3-ジオキシゲナーゼ 1 (IDO1) 活性の強力で選択的な脳浸透型阻害剤であり、成熟したヘム結合 IDO1 ではなくヘムを欠くアポ IDO1 に結合します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2166616-76-6
Sample solution is provided at 25 µL, 10mM.
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(S)-IDO1-IN-5 is the S-isomer of IDO1-IN-5. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1[1].
[1]. Frank C. Dorsey, et al. Abstract 5245: Identification and characterization of the IDO1 inhibitor LY3381916. Cancer Research. 2018, 78(13).
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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