Selective PI3Kδ Inhibitor 1 (compound 7n) |
| カタログ番号GC25913 |
選択的PI3Kδ阻害剤1（化合物7n）は、IC50が0.9 nMであり、他のクラスI PI3Kアイソフォーム[PI3Kα/β/γ=3670 / 1460 / 21300 nM]に対して1000倍以上の選択性を持つPI3Kδの阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2088525-31-7
Sample solution is provided at 25 µL, 10mM.
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Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM].
The compound shows reasonable pharmacokinetics with good bioavailability and moderate in vivo half-life. In rats, the oral bioavailability (F%) is 41, the Vss, T1/2 and CL are 2.8 L/kg, 3.4 h and 12 mL/min/kg respectively after IV administration[1].
[1] Terstiege I, et al. Bioorg Med Chem Lett. 2017, 27(3):679-687.
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