Spaglumic acid (Synonyms: NAAG, N-Acetylaspartylglutamic Acid, α-Spaglumic Acid) |
| カタログ番号GC14301 |
スパグルミン酸 (N-アセチルアスパルチルグルタミン酸) は、脳内にミリモル濃度で見られる神経ペプチドです。
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Cas No.: 3106-85-2
Sample solution is provided at 25 µL, 10mM.
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Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain.
Spaglumic Acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. Spaglumic Acid is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of Spaglumic Acid and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders[1].
References:
[1]. Coyle JT. The nagging question of the function of N-acetylaspartylglutamate. Neurobiol Dis. 1997;4(3-4):231-8.
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