Malachite green oxalate |
| カタログ番号GC61021 |
マラカイト グリーン シュウ酸塩は、酵素反応におけるリン酸の放出を検出するために使用できるトリフェニルメタン染料です。マラカイト グリーン シュウ酸塩は、IKBKE の強力かつ選択的な阻害剤でもあり、IκBα、p65、IRF3 などの下流の標的を阻害します。マラカイト グリーン シュウ酸塩は、in vitro および in vivo で抗腫瘍活性を示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2437-29-8
Sample solution is provided at 25 µL, 10mM.
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Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo[1][2][3].
[1]. Kozuka S, et, al. Permeability of dormant spores of Bacillus subtilis to malachite green and crystal violet. J Gen Microbiol. 1991 Mar; 137(3): 607-13. [2]. Takahashi S, et, al. Reversible off-on fluorescence probe for hypoxia and imaging of hypoxia-normoxia cycles in live cells. J Am Chem Soc. 2012 Dec 5; 134(48): 19588-91. [3]. Liu T, et, al. Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE. Cytokine. 2019 Apr; 116: 78-87.
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