StA-IFN-1 |
| カタログ番号GC44948 |
StA-IFN-1は、IFN誘導経路の阻害剤であり、IFN誘導に関するGFPレポーターアッセイにおいてIC50値が4.1μMであり、特定のIKKβ成分を阻害するTPCA-1と類似しています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 300839-31-0
Sample solution is provided at 25 µL, 10mM.
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StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 µM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective for the IFN induction pathway and not the IFN signaling pathway.
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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