Streptonigrin (Bruneomycin) (Synonyms: NSC 45383, NSC 56748, NSC 83950) |
| カタログ番号GC32303 |
ストレプトニグリン (ブルネオマイシン) (ブルネオマイシン)、Streptomyces flocculus によって生成される天然物は、抗腫瘍活性と抗菌活性の両方を持っています。
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Cas No.: 3930-19-6
Sample solution is provided at 25 µL, 10mM.
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Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively[1].
[1]. Dreyton CJ, et al. Insights into the mechanism of Streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem. 2014 Feb 15;22(4):1362-9.
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