Tafluprost ethyl amide (Synonyms: Taf EA, Tafluprost EA) |
| カタログ番号GC18573 |
タフルプロストエチルアミドはプロスタグランジン誘導体です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1185851-52-8
Sample solution is provided at 25 µL, 10mM.
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Tafluprost ethyl amide is derived from 17-phenyl trinor Prostaglandin F2α(17-phenyl trinor PGF2α). A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects. Alternatively, it was recently reported that analogs incorporating a 15-deoxy-15,15-difluoro modification also had a favorable ophthalmic activity profile. Tafluprost is a 2-series, 16-phenoxy analog of PGF2α with the 15,15-difluoro substitution. As a free acid, Tafluprost is a very potent FP receptor agonist (Ki = 0.4 nM). Ethyl amides of PGs tend to increase lipid solubility, to improve uptake into tissues and to further lower the effective concentration.
Review for Tafluprost ethyl amide
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
Review for Tafluprost ethyl amide
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