TAS 205 |
| カタログ番号GC48447 |
H-PGDSの阻害剤
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1584160-52-0
Sample solution is provided at 25 µL, 10mM.
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TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50 = 55.8 nM).1 It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 µM, as well as over enzyme and receptor panels at 10 µM. TAS 205 inhibits production of prostaglandin D2 induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50 values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sensitized guinea pig model of allergic rhinitis when administered at a dose of 30 mg/kg.
1.Aoyagi, H., Kajiwara, D., Tsunekuni, K., et al.Potential synergistic effects of novel hematopoietic prostaglandin D synthase inhibitor TAS-205 and different types of anti-allergic medicine on nasal obstruction in a Guinea pig model of experimental allergic rhinitisEur. J. Pharmacol.875173030(2020)
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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