Temozolomide Acid (Synonyms: Temozolomide 8-Carboxylic Acid, TMZA) |
| カタログ番号GC52076 |
テモゾロミド酸は、テモゾロミドのカルボン酸誘導体です。テモゾロミドは DNA アルキル化剤で、DNA のグアニン塩基とアデニン塩基をメチル化し、DNA 二本鎖の切断、細胞周期の停止、そして最終的に細胞死を引き起こします。テモゾロミド酸は、同じ抗癌活性を持つ親化合物テモゾロミドと同様の活性を持っています。
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Cas No.: 113942-30-6
Sample solution is provided at 25 µL, 10mM.
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Temozolomide acid is an active metabolite of the alkylating agent precursor temozolomide .1 It is cytotoxic to TLX5 murine lymphoma cells in a concentration-dependent manner. Temozolomide acid is also a synthetic intermediate in the synthesis of temozolomide prodrugs with anticancer activity.2
1.Tsang, L.L.H., Farmer, P.B., Gescher, A., et al.Characterisation of urinary metabolites of temozolomide in humans and mice and evaluation of their cytotoxicityCancer Chemother. Pharmacol.26(6)429-436(1990) 2.Liu, D., Yang, J.-G., Cheng, J., et al.Synthesis and antitumor activity of 3-methyl-4-oxo-3,4-dihydroimidazo [5,1-d][1,2,3,5]tetrazine-8-carboxylates and -carboxamidesMolecules15(12)9427-9437(2010)
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