TFMB-(S)-2-HG |
| カタログ番号GC65242 |
TFMB-(S)-2-HG は、5'-メチルシトシンヒドロキシラーゼ TET2 の強力な阻害剤です。 TFMB-(S)-2-HG は、EglN プロリルヒドロキシラーゼも阻害します。 TFMB-(S)-2-HG は、急性骨髄性白血病 (AML) の研究の可能性を秘めています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1445703-64-9
Sample solution is provided at 25 µL, 10mM.
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TFMB-(S)-2-HG is a potent inhibitor of the 5'-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML)[1].
[1]. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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