Thromboxane B2-d4 (Synonyms: TXB2-d4)

Thromboxane B₂-d₄ (TXB₂-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of TXB₂ by GC- or LC-mass spectrometry. TXB₂ is a stable, biologically inert metabolite formed from the non-enzymatic hydrolysis of TXA₂, which has a half-life of about 30 seconds.¹ Urinary analysis of TXB₂ accurately reflects intrarenal TXA₂ synthesis,² while measurement of 11-dehydro and 2,3-dinor thromboxane metabolites gives the best estimate of systemic TXA₂ secretion.^3,4

1.Needleman, P., Moncada, S., Bunting, S., et al.Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxidesNature261(5561)558-560(1976) 2.Patrono, C., Ciabattoni, G., Patrignani, P., et al.Evidence for a renal origin of urinary thromboxane B2 in health and diseaseAdv. Prostaglandin Thromboxane Leukot. Res.11493-498(1983) 3.Lawson, J.A., Patrono, C., Ciabattoni, G., et al.Long-lived enzymatic metabolites of thromboxane B2 in the human circulationAnal. Biochem.155(1)198-205(1986) 4.Patrono, C., Ciabattoni, G., Pugliese, F., et al.Estimated rate of thromboxane secretion into the circulation of normal humansJ. Clin. Invest.77(2)590-594(1986)