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TNO155

カタログ番号GC39514

TNO155 は、野生型 SHP2 の強力な選択的かつ経口活性のアロステリック阻害剤です (IC50=0.011 μM)。 TNO155 は、RTK 依存性悪性腫瘍、特に進行性固形腫瘍の研究に役立つ可能性があります。

Products are for research use only. Not for human use. We do not sell to patients.

TNO155 化学構造

Cas No.: 1801765-04-7

サイズ 価格 在庫数 個数
5mg
$216.00
在庫あり
10mg
$346.00
在庫あり
25mg
$725.00
在庫あり
50mg
$1,080.00
在庫あり
100mg
$1,231.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com

顧客レビュー

カスタマーレビューに基づきます。

  • GlpBio Citations

    GlpBio Citations
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors[1].

[1]. TNO155: SHP2 inhibitor

Chemical Properties

Cas No. 1801765-04-7 SDF
Canonical SMILES N[C@@H]1[C@H](C)OCC12CCN(C3=NC(N)=C(SC4=C(Cl)C(N)=NC=C4)N=C3)CC2
Formula C18H24ClN7OS M.Wt 421.95
溶解度 DMSO: 250 mg/mL (592.49 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.3699 mL 11.8497 mL 23.6995 mL
5 mM 0.474 mL 2.3699 mL 4.7399 mL
10 mM 0.237 mL 1.185 mL 2.3699 mL
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計算

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

レビュー

Review for TNO155

Average Rating: 5 ★★★★★ (Based on Reviews and 24 reference(s) in Google Scholar.)

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