Tromantadine hydrochloride |
| カタログ番号GC60373 |
抗ヘルペス活性を有するアマンタジン誘導体であるトロマンタジン塩酸塩は、単純ヘルペスウイルス1型（HSV-1）およびHSV-2の複製を阻害します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 41544-24-5
Sample solution is provided at 25 µL, 10mM.
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Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication[1].
Treatment of the cells with 10 to 50μg of Tromantadine reduces HSV-induced cytopathic effect. Treatment with 100 to 500μg of Tromantadine inhibits herpes simplex virus-induced cytopathic effect and reduces virus production. Complete inhibition of virus production is observed with treatments of 500μg to 1 mg. The antiherpetic activity of Tromantadine is dependent upon the viral inoculum size and the time of addition of the compound with respect to infection[1].
[1]. Rosenthal KS, et al. Tromantadine: inhibitor of early and late events in herpes simplex virus replication. Antimicrob Agents Chemother. 1982 Dec;22(6):1031-6.
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