UCL 2077 |
| カタログ番号GC13188 |
UCL 2077は過分極後のCa2+ チャネル、活動電位、入力抵抗、培地への影響を最小限に抑える、選択的なsAHP(slow-afterhyperpolarization)チャネル遮断薬(培養中の海馬ニューロンでIC50 =500 nM)です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 918311-87-2
Sample solution is provided at 25 µL, 10mM.
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UCL 2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker (IC50 = 500 nM in hippocampal neurons in culture), having minimal effects on Ca2+ channels, action potentials, input resistance and the medium after hyperpolarization[1]. UCL 2077 is also a subtype-selective blocker of the epilepsy associated KCNQ channels[2].
References:
[1]. Shah MM, et al. Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol Pharmacol. 2006 Nov;70(5):1494-502.
[2]. Soh H, et al. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol Pharmacol. 2010 Dec;78(6):1088-95.
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