UDP-GlcNAc Disodium Saltはヘキソサミン生物合成経路（HBP）[1]で生産され、グリコサミノグリカンなど、幾つかの重要な生物分子の前駆体として機能し、哺乳類のタンパク質の糖鎖付加のとても重要な基質である[2]。UDP-GlcNAc Disodium Saltは糖転移酵素のドナー基質であり、酵素は糖部分をタンパク質、脂質と核酸に付着させ、これは細胞シグナル伝達、粘着と免疫反応で重要な役割を果たしている[3]。UDP-GlcNAc Disodium Saltは主に、糖鎖生物学[4]と糖尿病[5]と癌[6]を含む代謝疾患に関する研究に使われている。
References:
[1]. Paneque A, Fortus H, Zheng J, et al. The Hexosamine Biosynthesis Pathway: Regulation and Function. Genes (Basel). 2023 Apr 18;14(4):933. doi: 10.3390/genes14040933. PMID: 37107691; PMCID: PMC10138107.
[2]. Ruegenberg S, Horn M, Pichlo C, et al. Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun. 2020 Feb 4;11(1):687. doi: 10.1038/s41467-020-14524-5. PMID: 32019926; PMCID: PMC7000685.
[3]. Yang X, Qian K. Protein O-GlcNAcylation: emerging mechanisms and functions. Nat Rev Mol Cell Biol. 2017 Jul;18(7):452-465. doi: 10.1038/nrm.2017.22. Epub 2017 May 10. PMID: 28488703; PMCID: PMC5667541.
[4]. van Wijk XM, Thijssen VL, Lawrence R, et al. Interfering with UDP-GlcNAc metabolism and heparan sulfate expression using a sugar analogue reduces angiogenesis. ACS Chem Biol. 2013 Oct 18;8(10):2331-8. doi: 10.1021/cb4004332. Epub 2013 Sep 3. PMID: 23972127; PMCID: PMC3821560.
[5]. Slawson C, Copeland RJ, Hart GW. O-GlcNAc signaling: a metabolic link between diabetes and cancer? Trends Biochem Sci. 2010 Oct;35(10):547-55. doi: 10.1016/j.tibs.2010.04.005. Epub 2010 May 11. PMID: 20466550; PMCID: PMC2949529.
[6]. Pan X, Wilson M, Mirbahai L, McConville C, Arvanitis TN, Griffin JL, Kauppinen RA, Peet AC. In vitro metabonomic study detects increases in UDP-GlcNAc and UDP-GalNAc, as early phase markers of cisplatin treatment response in brain tumor cells. J Proteome Res. 2011 Aug 5;10(8):3493-500. doi: 10.1021/pr200114v. Epub 2011 Jun 27. PMID: 21644796.