Valnoctamide (Synonyms: NSC 32363, NSC 34092, Valmethamide, Valoctamidum) |
| カタログ番号GC41613 |
バルプロ酸の誘導体であるバルノクタミド（バルメタミド）は、ベンゾジアゼピン抵抗性てんかん重積症を抑制します。
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Cas No.: 4171-13-5
Sample solution is provided at 25 µL, 10mM.
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Valnoctamide is an isomer of the valproic acid amide, valpromide. It has been marketed as an anxiolytic and sedative compound and suppresses neuropathic pain. Unlike valpromide, valnoctamide is not metabolized to its acid form, valnoctic acid, in vivo and has no teratogenicity. It abolishes the activity of myo-inositol-1-phosphate synthase in human brain crude homogenates (Ki = 0.18 mM). Valnoctamide suppresses electrographic seizures in animal models of status epilepticus, suggesting potential applications in managing epilepsy.
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