VU 0469650 hydrochloride |
| カタログ番号GC50154 |
VU 0469650 塩酸塩は、99 nM の IC50 を持つ、mGlu1 受容体の強力で選択的な CNS 透過性ネガティブ アロステリック モジュレーターです。
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Cas No.: 1443748-47-7
Sample solution is provided at 25 µL, 10mM.
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Potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM). Exhibits >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters. Brain penetrant.
Lovell et al (2013) N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg.Med.Chem.Lett. 23 3713 PMID:23727046
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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