WAY-161503 |
| カタログ番号GC45157 |
WAY-161503 は、4 nM の Ki と 12 nM の EC50 を持つ、強力で選択的な親和性の高い 5-HT2C 受容体アゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 75704-24-4
Sample solution is provided at 25 µL, 10mM.
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WAY-161503 is a full agonist of 5-HT2C receptors ). Relative to 5-HT2C receptor binding, WAY-161503 is ~6-fold less potent at 5-HT2A receptors (Ki = 18 nM) and 20-fold less potent at 5-HT2B receptors (Ki = 60 nM). In functional studies, WAY-161503 can stimulate calcium mobilization coupled to 5-HT2C, 2B, and 2A receptors with EC50 values of 0.8, 1.8, and 7 nM, respectively. WAY-161503 has been reported to produce dose-dependent decreases in food intake in 24-hour fasted normal Sprague-Dawley rats, diet-induced obese mice, and obese Zucker rats with ED50 values of 1.9, 6.8, and 0.73 mg/kg, respectively. This compound has been used to examine the role of 5-HT2C receptors in rodent models of depression, locomotion, reinforcement, or motivated behaviors.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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