YSK05 |
| カタログ番号GC52084 |
YSK05 は、pH に敏感なカチオン性脂質です。 YSK05 は、非ウイルスベクターの細胞内輸送を改善します。 YSK05-MEND は、非常に優れた遺伝子サイレンシング活性と溶血活性を示します。 YSK05 は、PEG 化によるエンドソーム エスケープの抑制を克服します。 YSK05 は、in vitro および in vivo の両方で siRNA 送達を効果的に強化します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1318793-78-0
Sample solution is provided at 25 µL, 10mM.
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YSK05 is an ionizable amino lipid (apparent pKa = ~6.5) that has been used in combination with other lipids in the formation of liposomes and lipid nanoparticles (LNPs).1,2,3 Administration of cyclic di-GMP in YSK05-containing liposomes increases serum levels of IFN-β, IFN-γ, IL-6, and TNF-α and activates natural killer (NK) cells in mice, as well as decreases lung metastasis in a B16/F10 murine melanoma model of metastasis.2 Intravenous administration of factor VII siRNA in YSK05-containing LNPs reduces factor VII activity in isolated mouse plasma.3
1.Sato, Y., Hatakeyama, H., Sakurai, Y., et al.A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivoJ. Control. Release163(3)267-276(2012) 2.Nakamura, T., Miyabe, H., Hyodo, M., et al.Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanomaJ. Control. Release216149-157(2015) 3.Sato, Y., Note, Y., Maeki, M., et al.Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA deliveryJ. Control. Release22948-57(2016)
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