YSK05 |
| Catalog No.GC52084 |
YSK05는 pH에 민감한 양이온성 지질입니다. YSK05는 비바이러스 벡터의 세포 내 트래피킹을 개선합니다. YSK05-MEND는 상당히 좋은 유전자 억제 활성과 용혈 활성을 나타냅니다. YSK05는 PEG화에 의한 엔도솜 탈출 억제를 극복합니다. YSK05는 시험관 내 및 생체 내 모두에서 siRNA 전달을 효과적으로 향상시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1318793-78-0
Sample solution is provided at 25 µL, 10mM.
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YSK05 is an ionizable amino lipid (apparent pKa = ~6.5) that has been used in combination with other lipids in the formation of liposomes and lipid nanoparticles (LNPs).1,2,3 Administration of cyclic di-GMP in YSK05-containing liposomes increases serum levels of IFN-β, IFN-γ, IL-6, and TNF-α and activates natural killer (NK) cells in mice, as well as decreases lung metastasis in a B16/F10 murine melanoma model of metastasis.2 Intravenous administration of factor VII siRNA in YSK05-containing LNPs reduces factor VII activity in isolated mouse plasma.3
1.Sato, Y., Hatakeyama, H., Sakurai, Y., et al.A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivoJ. Control. Release163(3)267-276(2012) 2.Nakamura, T., Miyabe, H., Hyodo, M., et al.Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanomaJ. Control. Release216149-157(2015) 3.Sato, Y., Note, Y., Maeki, M., et al.Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA deliveryJ. Control. Release22948-57(2016)
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