YZ129 |
| カタログ番号GC66059 |
YZ129 は、神経膠芽腫に対する HSP90-カルシニューリン-NFAT 経路の阻害剤であり、NFAT 核転座で 820 nM の IC50 で熱ショックタンパク質 90 (HSP90) に直接結合します。 G2 / M期でのYZ129誘発GBM細胞周期停止は、アポトーシスを促進し、腫瘍細胞の増殖と移動を阻害します。
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Cas No.: 1643120-60-8
Sample solution is provided at 25 µL, 10mM.
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YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1].
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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