YZ129 |
| Catalog No.GC66059 |
YZ129는 교모세포종에 대한 HSP90-칼시뉴린-NFAT 경로의 억제제로, NFAT 핵 전위에서 820nM의 IC50으로 열 충격 단백질 90(HSP90)에 직접 결합합니다. 821d96072c2d58d8970e76f526b0f6b8G2/M기에서 YZ129에 의해 유도된 GBM 세포주기 정지는 세포사멸을 촉진하고 종양 세포의 증식과 이동을 억제합니다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1643120-60-8
Sample solution is provided at 25 µL, 10mM.
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YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1].
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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