1-Naphthohydroxamic acid |
| Catalog No.GC39214 |
1-나프토히드록삼산(화합물 2)은 IC50이 14μM인 강력하고 선택적인 HDAC8 억제제입니다. 1-나프토히드록삼산은 클래스 I HDAC1 및 클래스 II HDAC6(IC50 >100μM)보다 HDAC8에 더 선택적으로 사용됩니다. 1-나프토히드록삼산은 전체 히스톤 H4 아세틸화를 증가시키지 않으며 또한 전체 세포내 HDAC 활성을 감소시키지 않습니다. 1-나프토히드록삼산은 튜불린 아세틸화를 유도할 수 있습니다.
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Cas No.: 6953-61-3
Sample solution is provided at 25 µL, 10mM.
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1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2].1-Naphthohydroxamic acid can induce tubulin acetylation[3].
[1]. Krennhrubec K, et al. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. [2]. Oehme I, et al. Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin Cancer Res. 2009 Jan 1;15(1):91-9.
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