2-Phenylethanol |
Catalog No.GC60484
One-Click Copy Product Info
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2-Phenylethanol은 장미 향기가 나는 중요한 향기로운 알코올이다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 60-12-8
Sample solution is provided at 25 µL, 10mM.
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2-Phenylethanol은 장미 향기가 나는 중요한 향기로운 알코올이다. 2-Phenylethanol은 항티로시나제 활성과 항균 활성이 있다[2]. 2-Phenylethanol은 식품, 향료, 화장품 산업에서 사용된다[3].
F. graminearum에서 2-Phenylethanol(0.6mg/mL, 1.2mg/mL, 2.4mg/mL; 14일)은 EC50 값이 0.328mg/mL인 F. graminearum의 균사 생장에 대해 우수한 억제력을 보였다[4]. A. hydrophila에서 2-Phenylethanol(1mg/mL; 24시간)은 A. hydrophila biofilm 형성을 현저하게 억제하였다[5].
C57BL/6 쥐에서 장미 오일(5% 2-Phenylethanol의 2㎖; 흡입; 15분)을 흡입하면 우울증과 스트레스 관련 질환에 대해 효과적일 수 있다[6]. 임신한 Long-Evans 쥐에서 2-Phenylethanol(4.3mg/kg, 43mg/kg, 430mg/kg; 경구 투여; 9일)은 후손에서 눈 기형, 신경관 결손증, 수신증, 사지 결손증의 발생률 증가로 나타난 주목할 만한 용량 관련 태아 독성 효과를 보였다[7]. C57BL/6 쥐에서 2-Phenylethanol(0.08% 2-Phenylethanol의 2㎖; 흡입; 하루 2시간씩 7일)은 쥐에서 불안 유사 행동 결함을 줄이기 위해 해마 내인성 대마초 신호전달을 조절한다[8].
References:
[1]. Hua D, Xu P. Recent advances in biotechnological production of 2-phenylethanol. Biotechnology advances. 2011 Nov 1; 29(6): 654-1660.
[2]. Zhu YJ, Zhou HT, Hu YH, et al. Antityrosinase and antimicrobial activities of 2-phenylethanol, 2-phenylacetaldehyde and 2-phenylacetic acid. Food Chemistry. 2011 Jan 1; 124(1): 298-302..
[3]. Chreptowicz K, Wielechowska M, Głowczyk-Zubek J, et al. Production of natural 2-phenylethanol: from biotransformation to purified product. Food and Bioproducts Processing. 2016 Oct 1; 100: 275-281.
[4]. Sun S, Tang N, Han K, et al. Effects of 2-phenylethanol on controlling the development of Fusarium graminearum in wheat. Microorganisms. 2023 Dec 10; 11(12): 2954.
[5]. Yin LJ, Wang W, Wang M, et al. 2-Phenylethanol in Endophytes of Areca catechu L. Inhibits the Biofilms and Virulence Against Aeromonas hydrophila. World Journal of Traditional Chinese Medicine. 2025: 10-4103.
[6]. Ueno H, Shimada A, Suemitsu S, et al. Anti-depressive-like effect of 2-phenylethanol inhalation in mice. Biomedicine & pharmacotherapy. 2019 Mar 1; 111: 1499-1506.
[7]. Mankes RF, LeFevre R, Bates H, et al. Effects of various exposure levels of 2‐phenylethanol on fetal development and survival in long‐Evans Rats. Journal of Toxicology and Environmental Health, Part A Current Issues. 1983 Aug 1; 12(2-3): 235-244.
[8]. Bi JR, Zha HW, Gao QL, et al. Pleasant Odor Decreases Mouse Anxiety-like Behaviors by Regulating Hippocampal Endocannabinoid Signaling. International Journal of Molecular Sciences. 2024 Oct 4; 25(19): 10699.
| 항균 실험 [1]: | |
박테리아 | F. graminearum |
제조 방법 | 밀 이삭에 대한 F. graminearum에 대한 2-Phenylethanol의 현장 효능 실험이 실시되었습니다. 개화기에는 F. graminearum의 10µL 포자 소생된 용액(5×10⁵ 포자/mL)으로 이삭을 접종하였습니다. 적당한 농도(0.6mg/mL, 1.2mg/mL, 2.4mg/mL)로 물에 희석된 2-Phenylethanol로 (Fielder, FHB에 감수성) 밀 이삭을 균일하게 뿌렸습니다. 같은 양의 물을 음성 대조 그룹(CK)으로 설정하고 215㎍/㎖의 tebuconazole을 양성 대조 그룹(CK1)으로 설정하였습니다. |
반응 조건 | 0.6mg/mL, 1.2mg/mL, 2.4mg/mL; 14 일 동안 |
응용 분야 | 2-Phenylethanol은 EC50 값이 0.328mg/mL인 F. graminearum의 균사 생장에 대해 우수한 억제력을 보였습니다. |
| 동물 실험 [2]: | |
동물 모형 | C57BL/6 쥐 |
제조 방법 | 5% 2-Phenylethanol 2㎖를 흡수한 흡수면 (4×4cm²)을 구멍이 있는 뚜껑으로 덮인 스테인리스 컨테이너 (60×60×35mm³)에 놓았습니다. 쥐들은 면을 핥거나 만질 수 없었습니다. 스테인리스 컨테이너는 더 큰 케이지 두 개(292×440×200mm³)로 둘러싸인 새 번식 케이지(235×325×170mm³)에 놓였습니다. 면을 놓은 후 약 15분 후에 쥐들은 내부 케이지에 15분 동안 놓였습니다. 흡입은 모든 행동 테스트 20분 전에 시작되었습니다. 2-Phenylethanol은 1% Tween 80(v/v)로 희석하여 5%(v/v)의 농도를 얻었습니다. |
제형 | 2mL of 5% 2-Phenylethanol; 흡입; 15 분 동안 |
응용 분야 | 2-Phenylethanol을 함유한 장미 오일의 흡입은 우울증과 스트레스 관련 질환에 효과가 있을 수 있습니다. |
References: | |
| Cas No. | 60-12-8 | SDF | |
| Canonical SMILES | OCCC1=CC=CC=C1 | ||
| Formula | C8H10O | M.Wt | 122.16 |
| Solubility | Water: 20 mg/mL (163.72 mM) | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 8.186 mL | 40.9299 mL | 81.8599 mL |
| 5 mM | 1.6372 mL | 8.186 mL | 16.372 mL |
| 10 mM | 818.6 μL | 4.093 mL | 8.186 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)