AMG 18 hydrochloride (Synonyms: AMG-18 Hydrochloride) |
Catalog No.GC50366 |
AMG 18 염산염(AMG-18 염산염)은 단일 선택성 IRE1α입니다. 알로스테릭하게 IRE1α를 약화시키는 억제제; IC50이 5.9nM인 RNase 활성.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2250019-92-0
Sample solution is provided at 25 µL, 10mM.
Potent and selective IRE1α inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.
Harrington et al (2014) Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med.Chem.Lett. 6 68 PMID:25589933
Average Rating: 5
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