AMG 18 hydrochloride (Synonyms: AMG-18 Hydrochloride) |
| カタログ番号GC50366 |
AMG 18 塩酸塩 (AMG-18 塩酸塩) は、モノ選択的 IRE1α です。 IRE1α をアロステリックに減衰させる阻害剤。 5.9 nM の IC50 を持つ RNase 活性。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2250019-92-0
Sample solution is provided at 25 µL, 10mM.
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Potent and selective IRE1α inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.
Harrington et al (2014) Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med.Chem.Lett. 6 68 PMID:25589933
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
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