AZD-7648 |
| Catalog No.GC64938 |
AZD-7648은 IC50이 0.6nM인 강력한 경구 활성 선택적 DNA-PK 억제제입니다. AZD-7648은 세포사멸을 유도하고 항종양 활성을 나타낸다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2230820-11-6
Sample solution is provided at 25 µL, 10mM.
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AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity[1].
AZD7648 (0-30 μM) is a potent radiosensitizer[1].AZD7648 (3 μM) increases sensitivity to doxorubicin[1].AZD7648 (0.6 μM) enhances the activity of PARP inhibitor olaparib[1].
AZD-7648 (100 mg/kg; p.o.; once daily for 5 days) induces tumour growth inhibition and tumour regression[1].
[1]. Fok JHL, et al. AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity. Nat Commun. 2019 Nov 7;10(1):5065.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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