BC-1215 |
| Catalog No.GC18487 |
BC-1215는 F-box 단백질 3(Fbxo3) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1507370-20-8
Sample solution is provided at 25 µL, 10mM.
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BC-1215 is an inhibitor of F-box protein 3 (FBXO3; IC50 = 0.9 μg/mL for Il-1β release). It decreases FBXO3 interaction with F-box/LRR-repeat protein 2 (FBXL2) in a dose-dependent manner and prevents FBXO3-dependent ubiquitination of FBXL2. It also lowers expression of Tnf receptor-associated factors (TRAFs) 1-6 without affecting TRAF1-6 mRNA levels in resting and LPS-stimulated peripheral blood mononuclear cells (PBMCs). BC-1215 (100 μg, i.p., per animal) reduces plasma levels of the inflammatory cytokines Il-6, Tnf, and Il-1β and decreases peritoneal bacteria counts in a mouse model of cecal ligation and puncture-induced sepsis. It also reduces inflammation in mouse models of DSS-induced colitis, paw edema, and ear edema.
Review for BC-1215
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
Review for BC-1215
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