TPN171 |
| Catalog No.GC37817 |
TPN171은 0.62 nM의 IC50을 갖는 PDE5(phosphodiesterase type 5)의 강력한 선택적 경구 생체이용 억제제로, 폐동맥 고혈압(PAH)의 치료를 위해 개발되고 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1229018-87-4
Sample solution is provided at 25 µL, 10mM.
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TPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH)[1]. PDE5|0.62 nM (IC50)
[1]. Wang Z, et al. Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. J Med Chem. 2019 May 23;62(10):4979-4990.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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