BI-3802 |
| Catalog No.GC32178 |
BI-3802는 매우 강력한 BCL6 분해제이며 ≤3 nM의 IC50으로 BCL6의 BTB(Bric-À-brac) 도메인을 억제합니다. BI-3802는 BCL6의 중합을 유도하고 E3 리가제 SIAH1에 의존하는 BCL6 분해를 촉진합니다. BI-3802는 항종양 활성이 있습니다.
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Cas No.: 2166387-65-9
Sample solution is provided at 25 µL, 10mM.
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BI-3802 is a highly potent BCL6 degrader, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3802 has antitumor activity.
BI-3802 is a BCL6 inhibitor, with an IC50 of ≤3 nM. BI-3802 shows an IC50 of 43 nM for the cellular BCL6[1].
[1]. Kerres N, et al. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep. 2017 Sep 19;20(12):2860-2875.
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