BI-3802 |
| Katalog-Nr.GC32178 |
BI-3802 ist ein hochpotenter BCL6-Abbaustoff und hemmt die Bric-À-brac (BTB)-DomÄne von BCL6 mit einem IC50 von ≤3 nM. BI-3802 induziert die Polymerisation von BCL6 und fÖrdert den Abbau von BCL6 in AbhÄngigkeit von der E3-Ligase SIAH1. BI-3802 hat AntitumoraktivitÄt.
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Cas No.: 2166387-65-9
Sample solution is provided at 25 µL, 10mM.
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BI-3802 is a highly potent BCL6 degrader, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3802 has antitumor activity.
BI-3802 is a BCL6 inhibitor, with an IC50 of ≤3 nM. BI-3802 shows an IC50 of 43 nM for the cellular BCL6[1].
[1]. Kerres N, et al. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep. 2017 Sep 19;20(12):2860-2875.
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